|Description:||Rabbit monoclonal antibody to Caveolin-1.|
|Applications:||WB, IHC, IF|
|Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:200, ICC 1:50 - 1:200, IF 1:50 - 1:100|
|Immunogen:||Recombinant protein of human CAV1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).|
|Tissue Specificity:||Expressed in muscle and lung, less so in liver, brain and kidney.|
|Involvement in Disease:||Congenital generalized lipodystrophy 3: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
Pulmonary hypertension, primary, 3: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome: A form of familial partial lipodystrophy associated with congenital cataracts and neurodegeneration leading to cerebellar and spinal cord dysfunction.
|Sequence Similarities:||Belongs to the caveolin family.|
|Post-Translational Modification:||The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.|
|Cellular Location:||Golgi apparatus membrane. Cell membrane. Membrane > Caveola. Membrane raft.
Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
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Western blot analysis of extracts of A431 cells, using CAV1 antibody.
Immunohistochemistry of paraffin-embedded mouse lung using CAV1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver using CAV1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using CAV1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse heart using CAV1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse liver using CAV1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of NIH-3T3 cell using CAV1 antibody.
Immunofluorescence analysis of A549 cell using CAV1 antibody.
Immunofluorescence analysis of MCF-7 cell using CAV1 antibody.