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Anti-Complement C3 (β- chain) Antibody

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ABclonal
A10766
Overview
Name: Anti-Complement C3 (β- chain) Antibody
Description: Mouse monoclonal antibody to Complement C3 (β- chain) .
Applications: WB, IF, FC
Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human C3
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
Tissue Specificity: Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods.
Involvement in Disease: Complement component 3 deficiency: A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis.

Macular degeneration, age-related, 9: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

Hemolytic uremic syndrome atypical 5: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Post-Translational Modification: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons.
Cellular Location: Secreted.
UniProt: P01024
Gene ID: 718
Synonyms: Acylation stimulating protein Antibody
Acylation stimulating protein cleavage product Antibody
Acylation-stimulating protein cleavage product Antibody
AHUS5 Antibody
AI255234 Antibody
ARMD9 Antibody
ASP Antibody
C3 Antibody
C3 / C3a Antibody
C3 / C3b Antibody
C3 and PZP like alpha 2 macroglobulin domain containing protein 1 Antibody
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 Antibody
C3a Antibody
C3a anaphylatoxin Antibody
C3adesArg Antibody
C3b Antibody
C3bc Antibody
C3c Antibody
C3d Antibody
C3g Antibody
CO3_HUMAN Antibody
Complement C3 alpha chain Antibody
Complement C3 beta chain Antibody
Complement C3b alpha' chain Antibody
Complement C3c Antibody
Complement C3c alpha' chain fragment 1 Antibody
Complement C3c alpha' chain fragment 2 Antibody
Complement C3c alpha'' chain fragment 2 Antibody
Complement C3d fragment Antibody
Complement C3dg fragment Antibody
Complement C3f fragment Antibody
Complement C3g fragment Antibody
Complement component 3 Antibody
Complement component 3d Antibody
Complement component C3 Antibody
Complement component C3a Antibody
Complement component C3b Antibody
Complement factor 3 Antibody
CPAMD1 Antibody
HEL S 62p Antibody
HSE MSF Antibody
omplement C3 beta chain Antibody
Plp Antibody
Prepro C3 Antibody

Images
Western Blot - Anti-Complement C3(β- chain) Antibody from ABclonal (A10766) - Antibody Supply Service
Western blot analysis of extracts of Human Plasma cells, using C3 antibody.

Product Code - A10766
Size Price Quantity
100µl £307
200µl £452

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