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Anti-DENND1A Antibody

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Name: Anti-DENND1A Antibody
Description: Rabbit polyclonal antibody to DENND1A.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human DENND1A
Protein Length: 1009 (559)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity).
Post-Translational Modification: Phosphorylated on serine and/or threonine in an Akt-dependent manner. Phosphorylation probably regulates the guanine nucleotide exchange factor (GEF) activity, possibly by disrupting an intramolecular interaction between the DENN domain and the C-terminus of the protein, thereby relieving the autoinhibition.
Cellular Location: Cytoplasmic vesicle > Clathrin-coated vesicle membrane. Cell junction > Synapse > Presynaptic cell membrane.

Associates to membranes via lipid-binding activity.
UniProt: Q8TEH3
Gene ID: 57706
Synonyms: Connecdenn Antibody
Connecdenn 1 Antibody
DEN1A_HUMAN Antibody
DENN domain-containing protein 1A Antibody
DENN/MADD domain containing 1A Antibody
FAM31A Antibody
FLJ21129 Antibody
FLJ38464 Antibody
KIAA1608 Antibody
OTTHUMP00000022090 Antibody
Protein FAM31A Antibody
RP11 230L22.3 Antibody

Product Code - A10758
Size Price Quantity
50µl £148
100µl £243
200µl £372

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