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Anti-Apolipoprotein A1 Antibody

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ABclonal
A10739
Overview
Name: Anti-Apolipoprotein A1 Antibody
Description: Mouse monoclonal antibody to Apolipoprotein A1.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100, IF 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human APOA1
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Tissue Specificity: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Involvement in Disease: High density lipoprotein deficiency 2: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.

High density lipoprotein deficiency 1: Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.

Amyloidosis 8: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
Sequence Similarities: Belongs to the apolipoprotein A1/A4/E family.
Post-Translational Modification: Glycosylated.
Cellular Location: Secreted.
UniProt: P02647
Gene ID: 335
Synonyms: Apo-AI Antibody
ApoA I Antibody
ApoA-I Antibody
APOA1 Antibody
APOA1_HUMAN Antibody
Apolipoprotein A I Antibody
Apolipoprotein A-I(1-242) Antibody
Apolipoprotein AI Antibody
Brp14 Antibody
Ltw1 Antibody
Lvtw1 Antibody
Sep1 Antibody
Sep2 Antibody

Images
Western Blot - Anti-Apolipoprotein A1 Antibody from ABclonal (A10739) - Antibody Supply Service
Western blot analysis of extracts of HepG2 cells, using APOA1 antibody.

Product Code - A10739
Size Price Quantity
100µl £307
200µl £452

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