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Anti-POLR3A Antibody

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ABclonal
A10737
Overview
Name: Anti-POLR3A Antibody
Description: Rabbit polyclonal antibody to POLR3A.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human POLR3A
Protein Length: 1390
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Tissue Specificity: Expressed in the brain, in the cortex and the white matter (at protein level).
Involvement in Disease: Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism: An autosomal recessive neurodegenerative disorder characterized by childhood onset of progressive motor decline manifest as spasticity, ataxia, tremor, and cerebellar signs, as well as mild cognitive regression. Other features may include hypodontia or oligodontia and hypogonadotropic hypogonadism. There is considerable inter- and intrafamilial variability.
Sequence Similarities: Belongs to the RNA polymerase beta' chain family.
Cellular Location: Nucleus.
UniProt: O14802
Gene ID: 11128
Synonyms: BC053071 Antibody
DNA directed RNA polymerase III largest subunit Antibody
DNA directed RNA polymerase III subunit A Antibody
DNA-directed RNA polymerase III largest subunit Antibody
DNA-directed RNA polymerase III subunit A Antibody
DNA-directed RNA polymerase III subunit RPC1 Antibody
hRPC155 Antibody
MGC62420 Antibody
POLR 3A Antibody
Polymerase (RNA) III (DNA directed) polypeptide A Antibody
Polymerase (RNA) III (DNA directed) polypeptide A 155kDa Antibody
RGD1305574 Antibody
RNA polymerase III 155 kDa subunit Antibody
RNA polymerase III subunit C1 Antibody
RNA polymerase III subunit C160 Antibody
RNA polymerase III subunit RPC155 D Antibody
RPC1 Antibody
RPC155 Antibody
RPC1_HUMAN Antibody

Images
Western Blot - Anti-POLR3A Antibody from ABclonal (A10737) - Antibody Supply Service
Western blot analysis of extracts of 293T cells, using POLR3A antibody.

Product Code - A10737
Size Price Quantity
50µl £148
100µl £243
200µl £372

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