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Anti-IL15RA Antibody

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Name: Anti-IL15RA Antibody
Description: Rabbit polyclonal antibody to IL15RA.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human IL15RA
Protein Length: 267
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.
Tissue Specificity: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
Post-Translational Modification: A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Cellular Location: Membrane. Nucleus membrane.

Mainly found associated with the nuclear membrane.
UniProt: Q13261
Gene ID: 3601
Synonyms: AA690181 Antibody
CD215 Antibody
I15RA_HUMAN Antibody
IL 15R alpha Antibody
IL-15 receptor subunit alpha Antibody
IL-15R-alpha Antibody
IL-15RA Antibody
Interleukin 15 receptor alpha Antibody
Interleukin 15 receptor subunit alpha Antibody
MGC104179 Antibody
sIL-15 receptor subunit alpha Antibody
sIL-15R-alpha Antibody
sIL-15RA Antibody
Soluble interleukin 15 receptor subunit alpha Antibody
Soluble interleukin-15 receptor subunit alpha Antibody

Product Code - A10732
Size Price Quantity
50µl £148
100µl £243
200µl £372

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