Anti-APC Protein AntibodyDatasheet
|Name:||Anti-APC Protein Antibody|
|Description:||Rat monoclonal (KT45) antibody to Adenomatous Polyposis Coli Protein (APC)|
|Antigen:||Adenomatous Polyposis Coli Protein (APC)|
|Amino Acid Start:||2170|
|Amino Acid End:||2394|
Target (Information from UniProt)
|Function:||Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity).|
|Tissue Specificity:||Expressed in liver, spleen, kidney, heart, lung, brain, stomach, intestine, testis and ovary.|
|Sequence Similarities:||Belongs to the adenomatous polyposis coli (APC) family.|
|Post-Translational Modification:||Phosphorylated by GSK3B.|
|Cellular Location:||Cell junction > Adherens junction. Cytoplasm > Cytoskeleton. Cell projection > Lamellipodium. Cell projection > Ruffle membrane. Cytoplasm. Cell membrane.
Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.