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Anti-CBX5 Antibody

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ABclonal
A10612
Overview
Name: Anti-CBX5 Antibody
Description: Mouse monoclonal antibody to CBX5.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human CBX5
Protein Length: 191
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Post-Translational Modification: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Cellular Location: Nucleus. Chromosome. Chromosome > Centromere.

Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
UniProt: P45973
Gene ID: 23468
Synonyms: Antigen p25 Antibody
CBX5_HUMAN Antibody
CG8409 Antibody
Chromobox 5 Antibody
Chromobox homolog 5 Antibody
Chromobox homolog 5 (HP1 alpha homolog, Drosophila) Antibody
Chromobox protein homolog 5 Antibody
Epididymis luminal protein 25 Antibody
HEL25 Antibody
Heterochromatin protein 1 Antibody
Heterochromatin protein 1 alpha Antibody
Heterochromatin protein 1 homolog alpha Antibody
HP1 Antibody
HP1 alpha Antibody
HP1 alpha (phospho S92) Antibody
HP1 alpha homolog Antibody
HP1A Antibody
HP1Hs alpha Antibody
Su(var)205 Antibody

Images
Western Blot - Anti-CBX5 Antibody from ABclonal (A10612) - Antibody Supply Service
Western blot analysis of extracts of various cells, using CBX5 antibody.

Product Code - A10612
Size Price Quantity
50µl £199
100µl £307
200µl £452

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