|Description:||Mouse monoclonal antibody to CBX5.|
|Dilutions:||WB 1:500 - 1:1000, IHC 1:50 - 1:200|
|Immunogen:||Recombinant protein of human CBX5|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.|
|Post-Translational Modification:||Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.|
|Cellular Location:||Nucleus. Chromosome. Chromosome > Centromere.
Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
|Synonyms:||Antigen p25 Antibody
Chromobox 5 Antibody
Chromobox homolog 5 Antibody
Chromobox homolog 5 (HP1 alpha homolog, Drosophila) Antibody
Chromobox protein homolog 5 Antibody
Epididymis luminal protein 25 Antibody
Heterochromatin protein 1 Antibody
Heterochromatin protein 1 alpha Antibody
Heterochromatin protein 1 homolog alpha Antibody
HP1 alpha Antibody
HP1 alpha (phospho S92) Antibody
HP1 alpha homolog Antibody
HP1Hs alpha Antibody
Western blot analysis of extracts of various cells, using CBX5 antibody.