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Anti-PIK3R1 Antibody

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ABclonal
A10608
Overview
Name: Anti-PIK3R1 Antibody
Description: Mouse monoclonal antibody to PIK3R1.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human PIK3R1
Protein Length: 724
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Tissue Specificity: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Involvement in Disease: Agammaglobulinemia 7, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

SHORT syndrome: A rare, multisystem disease characterized by short stature, anomalies of the anterior chamber of the eye, characteristic facial features such as triangular facies, lack of facial fat, and hypoplastic nasal alae with overhanging columella, partial lipodystrophy, hernias, hyperextensibility, and delayed dentition. The clinical phenotype can include insulin resistance, nephrocalcinosis, and hearing deficits. Developmental milestones and cognition are normal.

Immunodeficiency 36: A primary immunodeficiency characterized by impaired B-cell function, hypogammaglobulinemia and recurrent infections.
Sequence Similarities: Belongs to the PI3K p85 subunit family.
Post-Translational Modification: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
UniProt: P27986
Gene ID: 5295
Synonyms: 5-bisphosphate 3-kinase 110 kDa catalytic subunit delta Antibody
5-bisphosphate 3-kinase catalytic subunit delta isoform Antibody
APDS Antibody
GRB 1 Antibody
GRB1 Antibody
IMD14 Antibody
p110d Antibody
p110delta Antibody
p110dp85a Antibody
p55 Antibody
p55 GAMMA Antibody
p85 Antibody
p85 alpha Antibody
p85 BETA Antibody
p85-ALPHA Antibody
P85A_HUMAN Antibody
P85B Antibody
Phosphatidylinositol 3 kinase associated p 85 alpha Antibody
Phosphatidylinositol 3 kinase associated p85 alpha Antibody
Phosphatidylinositol 3 kinase associated p85 gamma Antibody
Phosphatidylinositol 3 kinase catalytic delta polypeptide Antibody
Phosphatidylinositol 3 kinase regulatory 1 Antibody
Phosphatidylinositol 3 kinase regulatory 3 Antibody
Phosphatidylinositol 3 kinase regulatory subunit alpha Antibody
Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha) Antibody
Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) Antibody
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha Antibody
Phosphatidylinositol 3-kinase regulatory subunit alpha Antibody
Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform Antibody
Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit delta Antibody
Phosphatidylinositol 4,5 bisphosphate 3 kinase, catalytic subunit delta Antibody
Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform Antibody
Phosphatidylinositol-4 Antibody
Phosphoinositide 3 kinase B Antibody
Phosphoinositide 3 kinase C Antibody
Phosphoinositide 3 kinase catalytic delta polypeptide Antibody
Phosphoinositide 3 kinase regulatory subunit 1 Antibody
Phosphoinositide 3 kinase regulatory subunit 1 (alpha) Antibody
Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha) Antibody
Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha) Antibody
Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta Antibody
Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) Antibody
PI 3 Kinase p110 delta Antibody
PI 3 Kinase p85 (SH2) Antibody
PI 3 Kinase p85 alpha Antibody
PI 3 Kinase p85 alpha + Gamma Antibody
PI3 kinase p110 subunit delta Antibody
PI3 kinase p85 subunit alpha Antibody
PI3 kinase p85 subunit beta Antibody
PI3-kinase regulatory subunit alpha Antibody
PI3-kinase subunit delta Antibody
PI3-kinase subunit p85-alpha Antibody
PI3K Antibody
PI3K p85 Antibody
PI3K p85 (phospho Y607) Antibody
PI3K regulatory subunit alpha Antibody
PI3K-delta Antibody
PI3Kdelta Antibody
Pik3cd Antibody
PIK3R2 Antibody
PIK3R3 Antibody
PK3CD Antibody
PK3CD_HUMAN Antibody
PtdIns 3 kinase p110 Antibody
PtdIns 3 kinase p85 alpha Antibody
PtdIns 3 kinase p85 gamma Antibody
PtdIns 3 kinase subunit p110 delta Antibody
PtdIns-3-kinase regulatory subunit alpha Antibody
PtdIns-3-kinase regulatory subunit p85-alpha Antibody
PtdIns-3-kinase subunit delta Antibody
PtdIns-3-kinase subunit p110-delta Antibody

Images
Western Blot - Anti-PIK3R1 Antibody from ABclonal (A10608) - Antibody Supply Service
Western blot analysis of extracts of various cells, using PIK3R1 antibody.

Product Code - A10608
Size Price Quantity
100µl £307
200µl £452

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