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Anti-WDR11 Antibody

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ABclonal
A10590
Details
Description: Rabbit polyclonal antibody to WDR11.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q9BZH6
Gene ID: 55717
Immunogen: Recombinant protein of human WDR11
Protein Length: 1224
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: DR11; HH14; SRI1; BRWD2; WDR15
Purification: Affinity purification
Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:1000 - 1:2000

Target (Information from UniProt)
Tissue Specificity: Ubiquitous.
Involvement in Disease: Hypogonadotropic hypogonadism 14 with or without anosmia: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Cellular Location: Membrane. Cytoplasm. Nucleus.

Might be shuttling between the nucleus and the cytoplasm.

Images
Western Blot - Anti-WDR11 Antibody from ABclonal (A10590) - Antibody Supply Service
Western blot analysis of extracts of various cells, using WDR11 antibody.

Product Code - A10590
Size Price Quantity
50µl £148
100µl £243
200µl £372

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