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Anti-AP1S1 Antibody

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ABclonal
A10558
Details
Description: Rabbit polyclonal antibody to AP1S1.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P61966
Gene ID: 1174
Immunogen: Recombinant protein of human AP1S1
Protein Length: 158
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: AP19; EKV3; CLAPS1; MEDNIK; SIGMA1A
Purification: Affinity purification
Background: The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000

Target (Information from UniProt)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Tissue Specificity: Widely expressed.
Involvement in Disease: Mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma: A disorder characterized by erythematous skin lesions and hyperkeratosis, severe psychomotor retardation, peripheral neuropathy, sensorineural hearing loss, together with elevated very-long-chain fatty acids and severe congenital diarrhea.
Sequence Similarities: Belongs to the adaptor complexes small subunit family.
Cellular Location: Golgi apparatus. Cytoplasmic vesicle membrane. Membrane > Clathrin-coated pit.

Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Images
Western Blot - Anti-AP1S1 Antibody from ABclonal (A10558) - Antibody Supply Service
Western blot analysis of extracts of SW480 cells, using AP1S1 antibody.

Product Code - A10558
Size Price Quantity
50µl £148
100µl £243
200µl £372

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