|Description:||Rabbit polyclonal antibody to TRIM24.|
|Dilutions:||WB 1:1000 - 1:2000|
|Immunogen:||Recombinant protein of human TRIM24|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).|
|Cellular Location:||Nucleus. Cytoplasm.
Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.
|Synonyms:||E3 ubiquitin protein ligase TRIM24 Antibody
E3 ubiquitin-protein ligase Trim24 Antibody
RING finger protein 82 Antibody
TIF1 alpha Antibody
Transcription intermediary factor 1-alpha Antibody
Transcriptional intermediary factor 1 Antibody
Transcriptional intermediary factor 1 alpha Antibody
Tripartite motif containing 24 Antibody
Tripartite motif-containing protein 24 Antibody
Western blot analysis of extracts of various cells, using TRIM24 antibody.