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Anti-VDAC3 Antibody

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ABclonal
A10544
Details
Description: Rabbit polyclonal antibody to VDAC3.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q9Y277
Gene ID: 7419
Immunogen: Recombinant protein of human VDAC3
Protein Length: 283
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: VDAC-3; HD-VDAC3
Purification: Affinity purification
Background: This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:1000 - 1:2000

Target (Information from UniProt)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Tissue Specificity: Widely expressed. Highest in testis.
Sequence Similarities: Belongs to the eukaryotic mitochondrial porin family.
Post-Translational Modification: Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Cellular Location: Mitochondrion outer membrane.

Images
Western Blot - Anti-VDAC3 Antibody from ABclonal (A10544) - Antibody Supply Service
Western blot analysis of extracts of A431 cells, using VDAC3 antibody.

Product Code - A10544
Size Price Quantity
50µl £148
100µl £243
200µl £372

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