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Anti-Histone H3 (tri methyl K27) Antibody

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Name: Anti-Histone H3 (tri methyl K27) Antibody
Description: Mouse monoclonal antibody to Histone H3 (tri methyl K27).
Applications: WB, IF
Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:100
Reactivity: Human
Immunogen: A specific peptide of human TriMethyl-Histone H3-K27
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Tissue Specificity: Expressed in testicular cells.
Sequence Similarities: Belongs to the histone H3 family.
Post-Translational Modification: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
Cellular Location: Nucleus. Chromosome.
UniProt: Q16695
Gene ID: 8290
Synonyms: H3 histone family, member A Antibody
H3/A Antibody
H31_HUMAN Antibody
H3FA Antibody
Hist1h3a Antibody
HIST1H3B Antibody
HIST1H3C Antibody
HIST1H3D Antibody
HIST1H3E Antibody
HIST1H3F Antibody
HIST1H3G Antibody
HIST1H3H Antibody
HIST1H3I Antibody
HIST1H3J Antibody
histone 1, H3a Antibody
Histone cluster 1, H3a Antibody
Histone H3.1 Antibody
Histone H3/a Antibody
Histone H3/b Antibody
Histone H3/c Antibody
Histone H3/d Antibody
Histone H3/f Antibody
Histone H3/h Antibody
Histone H3/i Antibody
Histone H3/j Antibody
Histone H3/k Antibody
Histone H3/l Antibody

Product Code - A10529
Size Price Quantity
100µl £307
200µl £452

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