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Anti-VEGF Receptor 1 Antibody

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ABclonal
A10524
Overview
Name: Anti-VEGF Receptor 1 Antibody
Description: Mouse monoclonal antibody to VEGF Receptor 1.
Applications: WB
Dilutions: WB 1:200 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human FLT1
Protein Length: 1338
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
Tissue Specificity: Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Post-Translational Modification: N-glycosylated.
Cellular Location: Cell membrane. Endosome.

Autophosphorylation promotes ubiquitination and endocytosis.
UniProt: P17948
Gene ID: 2321
Synonyms: EC 2.7.10.1 Antibody
FLT Antibody
FLT 1 Antibody
Flt-1 Antibody
FLT1 Antibody
Fms like tyrosine kinase 1 Antibody
Fms related tyrosine kinase 1 Antibody
Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Antibody
Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor Antibody
Fms-like tyrosine kinase 1 Antibody
FRT Antibody
Soluble VEGF receptor 1 14 Antibody
Soluble VEGFR1 variant 2 Antibody
Soluble VEGFR1 variant 21 Antibody
Tyrosine protein kinase FRT Antibody
Tyrosine protein kinase receptor FLT Antibody
Tyrosine-protein kinase FRT Antibody
Tyrosine-protein kinase receptor FLT Antibody
Vascular endothelial growth factor receptor 1 Antibody
Vascular endothelial growth factor vascular permeability factor receptor Antibody
Vascular permeability factor receptor Antibody
Vascular permeability factor receptor 1 Antibody
VEGFR 1 Antibody
VEGFR-1 Antibody
VEGFR1 Antibody
VGFR1_HUMAN Antibody

Images
Western Blot - Anti-VEGF Receptor 1 Antibody from ABclonal (A10524) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using FLT1antibody.

Product Code - A10524
Size Price Quantity
100µl £243
200µl £372

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