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Anti-SMAD7 Antibody

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ABclonal
A1051
Overview
Name: Anti-SMAD7 Antibody
Description: Rabbit polyclonal antibody to SMAD7.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: Recombinant protein of human SMAD7
Protein Length: 426
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Tissue Specificity: Ubiquitous with higher expression in the lung and vascular endothelium.
Involvement in Disease: Colorectal cancer 3: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Sequence Similarities: Belongs to the dwarfin/SMAD family.
Post-Translational Modification: Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1.
Cellular Location: Nucleus. Cytoplasm.

Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236).
UniProt: O15105
Gene ID: 4092
Synonyms: CRCS3 Antibody
FLJ16482 Antibody
hSMAD 7 Antibody
hSMAD7 Antibody
MAD Antibody
MAD (mothers against decapentaplegic Drosophila) homolog 7 Antibody
Mad homolog 7 Antibody
MAD homolog 8 Antibody
MAD mothers against decapentaplegic homolog 7 Antibody
MADH 7 Antibody
MADH 8 Antibody
MADH6 Antibody
MADH7 Antibody
MADH8 Antibody
Mothers Against Decapentaplegic Drosophila Homolog of 6 Antibody
Mothers Against Decapentaplegic Drosophila Homolog of 7 Antibody
Mothers against decapentaplegic homolog 7 Antibody
Mothers against decapentaplegic homolog 8 Antibody
Mothers against DPP homolog 7 Antibody
Mothers against DPP homolog 8 Antibody
SMA- AND MAD-RELATED PROTEIN 7 Antibody
SMAD Antibody
SMAD 7 Antibody
SMAD family member 7 Antibody
SMAD, mothers against DPP homolog 7 Antibody
SMAD, mothers against DPP homolog 7 (Drosophila) Antibody
SMAD6 Antibody
SMAD7_HUMAN Antibody

Images
Western Blot - Anti-SMAD7 Antibody from ABclonal (A1051) - Antibody Supply Service
Western blot analysis of extracts of SW480 cells, using SMAD7 antibody.

Product Code - A1051
Size Price Quantity
50µl £148
100µl £243
200µl £372

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