|Description:||Rabbit polyclonal antibody to RASGRP1.|
|Dilutions:||WB 1:1000 - 1:2000|
|Immunogen:||Recombinant protein of human RASGRP1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).|
|Tissue Specificity:||Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).|
|Involvement in Disease:||Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.|
|Sequence Similarities:||Belongs to the RASGRP family.|
|Cellular Location:||Cytoplasm > Cytosol. Cell membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.
Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity).
|Synonyms:||Calcium and DAG-regulated guanine nucleotide exchange factor II Antibody
Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A Antibody
Ras activator RasGRP Antibody
RAS guanyl nucleotide releasing protein 1 Antibody
RAS guanyl releasing protein 1 Antibody
RAS guanyl releasing protein 1 (calcium and DAG-regulated) Antibody
Western blot analysis of extracts of various cells, using RASGRP1 antibody.