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Anti-RASGRP1 Antibody

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ABclonal
A10495
Overview
Name: Anti-RASGRP1 Antibody
Description: Rabbit polyclonal antibody to RASGRP1.
Applications: WB
Dilutions: WB 1:1000 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human RASGRP1
Protein Length: 797
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).
Tissue Specificity: Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).
Involvement in Disease: Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Sequence Similarities: Belongs to the RASGRP family.
Cellular Location: Cytoplasm > Cytosol. Cell membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.

Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity).
UniProt: O95267
Gene ID: 10125
Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor II Antibody
CALDAG-GEFI Antibody
CALDAG-GEFII Antibody
Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A Antibody
hRasGRP1 Antibody
Ras activator RasGRP Antibody
RAS guanyl nucleotide releasing protein 1 Antibody
RAS guanyl releasing protein 1 Antibody
RAS guanyl releasing protein 1 (calcium and DAG-regulated) Antibody
RASGRP Antibody
V Antibody

Images
Western Blot - Anti-RASGRP1 Antibody from ABclonal (A10495) - Antibody Supply Service
Western blot analysis of extracts of various cells, using RASGRP1 antibody.

Product Code - A10495
Size Price Quantity
50µl £148
100µl £243
200µl £372

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