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Anti-DDR1 Antibody

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Name: Anti-DDR1 Antibody
Description: Rabbit polyclonal antibody to DDR1.
Applications: WB
Dilutions: WB 1:1000 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human DDR1
Protein Length: 913 (894)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Tissue Specificity: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Post-Translational Modification: Autophosphorylated in response to fibrillar collagen binding.
Cellular Location: Cell membrane.
UniProt: Q08345
Gene ID: 780
Synonyms: CAK Antibody
CD 167 Antibody
CD167 Antibody
CD167 antigen-like family member A Antibody
CD167a Antibody
Cell adhesion kinase Antibody
DDR Antibody
DDR 1 Antibody
DDR1_HUMAN Antibody
Discoidin domain receptor Antibody
Discoidin domain receptor tyrosine kinase 1 Antibody
Discoidin receptor tyrosine kinase Antibody
Discoidin receptor tyrosine kinase isoform a Antibody
EDDR 1 Antibody
EDDR1 Antibody
Epithelial discoidin domain receptor 1 Antibody
Epithelial discoidin domain-containing receptor 1 Antibody
Epithelial specific receptor kinase Antibody
HGK2 Antibody
Mammarian carcinoma kinase 10 Antibody
Mammary carcinoma kinase 10 Antibody
MCK-10 Antibody
MCK10 Antibody
MCK10 (phospho Y513) Antibody
NEP Antibody
Neuroepithelial tyrosine kinase Antibody
Neurotrophic tyrosine kinase receptor type 4 Antibody
NTRK 4 Antibody
NTRK4 Antibody
OTTHUMP00000029343 Antibody
OTTHUMP00000029344 Antibody
OTTHUMP00000029345 Antibody
OTTHUMP00000029346 Antibody
OTTHUMP00000029347 Antibody
OTTHUMP00000164863 Antibody
OTTHUMP00000164867 Antibody
OTTHUMP00000222080 Antibody
Protein-tyrosine kinase 3A Antibody
Protein-tyrosine kinase RTK-6 Antibody
PTK 3 Antibody
PTK 3A protein tyrosine kinase 3A Antibody
PTK3 Antibody
PTK3A Antibody
Receptor tyrosine kinase NEP Antibody
RTK 6 Antibody
RTK6 Antibody
TRK E Antibody
TRKE Antibody
Tyrosine kinase DDR Antibody
Tyrosine kinase receptor E Antibody
Tyrosine-protein kinase CAK Antibody

Western Blot - Anti-DDR1 Antibody from ABclonal (A10487) - Antibody Supply Service
Western blot analysis of extracts of various cells, using DDR1 antibody.

Product Code - A10487
Size Price Quantity
50µl £148
100µl £243
200µl £372

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