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Anti-ULBP1 Antibody

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ABclonal
A10483
Overview
Name: Anti-ULBP1 Antibody
Description: Rabbit polyclonal antibody to ULBP1.
Applications: WB
Dilutions: WB 1:1000 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human ULBP1
Protein Length: 244
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Tissue Specificity: Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Sequence Similarities: Belongs to the MHC class I family.
Cellular Location: Cell membrane. Endoplasmic reticulum.

Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
UniProt: Q9BZM6
Gene ID: 80329
Synonyms: Alcan beta Antibody
ALCAN-beta Antibody
N2DL-1 Antibody
N2DL1 Antibody
N2DL1_HUMAN Antibody
NKG2D ligand 1 Antibody
NKG2D ligand 1 precursor Antibody
NKG2DL1 Antibody
RAET1I Antibody
Retinoic acid early transcript 1I Antibody
UL16 Antibody
UL16 binding protein 1 Antibody
UL16-binding protein 1 Antibody

Images
Western Blot - Anti-ULBP1 Antibody from ABclonal (A10483) - Antibody Supply Service
Western blot analysis of extracts of Raji cells, using ULBP1 antibody.

Product Code - A10483
Size Price Quantity
50µl £148
100µl £243
200µl £372

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