|Description:||Rabbit polyclonal antibody to ULBP1.|
|Dilutions:||WB 1:1000 - 1:2000|
|Immunogen:||Recombinant protein of human ULBP1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.|
|Tissue Specificity:||Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.|
|Sequence Similarities:||Belongs to the MHC class I family.|
|Cellular Location:||Cell membrane. Endoplasmic reticulum.
Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
|Synonyms:||Alcan beta Antibody
NKG2D ligand 1 Antibody
NKG2D ligand 1 precursor Antibody
Retinoic acid early transcript 1I Antibody
UL16 binding protein 1 Antibody
UL16-binding protein 1 Antibody
Western blot analysis of extracts of Raji cells, using ULBP1 antibody.