|Description:||Rabbit polyclonal antibody to NFKBIL1.|
|Immunogen:||Recombinant protein of human NFKBIL1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonyms:||IKBL; LST1; NFKBIL|
|Background:||This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:2000|
Target (Information from UniProt)
|Function:||Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.|
|Tissue Specificity:||Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.|
|Involvement in Disease:||Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.|
Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
Western blot analysis of extracts of various cell lines, using NFKBIL1 antibody.