|Description:||Rabbit polyclonal antibody to NFKBIL1.|
|Dilutions:||WB 1:500 - 1:2000|
|Immunogen:||Recombinant protein of human NFKBIL1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.|
|Tissue Specificity:||Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.|
|Involvement in Disease:||Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.|
Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
|Synonyms:||I-kappa-B-like protein Antibody
Inhibitor of kappa B-like protein Antibody
NF-kappa-B inhibitor-like protein 1 Antibody
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 Antibody
Western blot analysis of extracts of various cell lines, using NFKBIL1 antibody.