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Anti-DMPK Antibody

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ABclonal
A10442
Overview
Name: Anti-DMPK Antibody
Description: Rabbit polyclonal antibody to DMPK.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human DMPK
Protein Length: 639 (629)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Tissue Specificity: Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
Involvement in Disease: Dystrophia myotonica 1: A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Post-Translational Modification: Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK.
Cellular Location: Endoplasmic reticulum membrane. Nucleus outer membrane. Mitochondrion outer membrane. Sarcoplasmic reticulum membrane. Cell membrane. Cytoplasm > Cytosol.

Localizes to sarcoplasmic reticulum membranes of cardiomyocytes.
UniProt: Q09013
Gene ID: 1760
Synonyms: DM Antibody
DM 1 Antibody
DM kinase Antibody
DM protein kinase Antibody
DM-kinase Antibody
DM1 Antibody
DM1 protein kinase Antibody
DM1PK Antibody
DMK Antibody
DMPK_HUMAN Antibody
Dystrophia myotonica 1 Antibody
Dystrophia myotonica protein kinase Antibody
MDPK Antibody
MT PK Antibody
MT-PK Antibody
Myotonic dystrophy associated protein kinase Antibody
Myotonic dystrophy protein kinase Antibody
Myotonin protein kinase Antibody
Myotonin protein kinase A Antibody
Myotonin-protein kinase Antibody
Thymopoietin homolog Antibody

Images
Western Blot - Anti-DMPK Antibody from ABclonal (A10442) - Antibody Supply Service
Western blot analysis of extracts of A549 cells, using DMPK antibody.

Product Code - A10442
Size Price Quantity
50µl £148
100µl £243
200µl £372

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