|Description:||Rabbit polyclonal antibody to JTB.|
|Dilutions:||WB 1:500 - 1:2000|
|Immunogen:||Recombinant protein of human JTB|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).|
|Tissue Specificity:||Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.|
|Sequence Similarities:||Belongs to the JTB family.|
|Cellular Location:||Membrane. Mitochondrion. Cytoplasm. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle.
Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Jumping translocation breakpoint Antibody
Jumping translocation breakpoint protein Antibody
PAR protein Antibody
Prostate androgen regulated protein Antibody
Prostate androgen-regulated protein Antibody
Protein JTB Antibody
Western blot analysis of extracts of various cell lines, using JTB antibody.