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Anti-COLEC12 Antibody

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ABclonal
A10422
Overview
Name: Anti-COLEC12 Antibody
Description: Rabbit polyclonal antibody to COLEC12.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human COLEC12
Protein Length: 742
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
Tissue Specificity: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
Cellular Location: Membrane.

Forms clusters on the cell surface.
UniProt: Q5KU26
Gene ID: 81035
Synonyms: CL P1 Antibody
CL-P1 Antibody
CLP1 Antibody
COL12_HUMAN Antibody
COLEC 12 Antibody
Collectin placenta 1 Antibody
Collectin placenta protein 1 Antibody
Collectin sub family member 12 Antibody
Collectin-12 Antibody
hCL P1 Antibody
hCL-P1 Antibody
NSR2 Antibody
Nurse cell scavenger receptor 2 Antibody
SCARA4 Antibody
Scavenger receptor class A member 4 Antibody
Scavenger receptor with C type lectin Antibody
Scavenger receptor with C-type lectin Antibody
SRCL Antibody

Images
Western Blot - Anti-COLEC12 Antibody from ABclonal (A10422) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using COLEC12 antibody.

Product Code - A10422
Size Price Quantity
50µl £148
100µl £243
200µl £372

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