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Anti-SLC39A14 Antibody

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ABclonal
A10413
Overview
Name: Anti-SLC39A14 Antibody
Description: Rabbit polyclonal antibody to SLC39A14.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human SLC39A14
Protein Length: 492 (481)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.
Tissue Specificity: Expressed in liver and in brain by large neurons in the globus pallidus, the insular cortex and the dentate nucleus and to a lower extent in the putamen and the caudate nucleus (at protein level) (PubMed:27231142). Isoform 1 is ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes (PubMed:15642354, PubMed:7584044, PubMed:27231142). Isoform 3 is widely expressed but not detected in brain, heart, skeletal muscle and fetal skin (PubMed:27231142).
Involvement in Disease: Hypermanganesemia with dystonia 2: A metabolic autosomal recessive disorder characterized by increased blood manganese levels, neurodegeneration, and rapidly progressive parkinsonism and dystonia. Affected individuals present with loss of developmental milestones, progressive dystonia and bulbar dysfunction in infancy or early childhood. Towards the end of the first decade, they manifest severe generalized pharmacoresistant dystonia, spasticity, limb contractures and scoliosis, and loss of independent ambulation. Cognition may be impaired, but is better preserved than motor function.
Sequence Similarities: Belongs to the ZIP transporter (TC 2.A.5) family.
Cellular Location: Cell membrane. Cytoplasm. Cell projection > Lamellipodium.

Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
UniProt: Q15043
Gene ID: 23516
Synonyms: Cig19 Antibody
KIAA0062 Antibody
LIV-1 subfamily of ZIP zinc transporter 4 Antibody
LZT-Hs4 Antibody
NET34 Antibody
S39AE_HUMAN Antibody
Solute carrier family 39 (zinc transporter), member 14 Antibody
Solute carrier family 39 member 14 Antibody
Zinc transporter ZIP14 Antibody
ZIP-14 Antibody
ZIP14 Antibody
Zrt Irt like protein 14 Antibody
Zrt- and Irt-like protein 14 Antibody

Images
Western Blot - Anti-SLC39A14 Antibody from ABclonal (A10413) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using SLC39A14 antibody.

Product Code - A10413
Size Price Quantity
50µl £148
100µl £243
200µl £372

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