phone icon
+44 (0)1223 298875

Anti-USP2 Antibody

file icon Datasheet
ABclonal
A10399
Overview
Name: Anti-USP2 Antibody
Description: Rabbit polyclonal antibody to USP2.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human USP2
Protein Length: 605
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
Tissue Specificity: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
Sequence Similarities: Belongs to the peptidase C19 family. USP2 subfamily.
Cellular Location: Cytoplasm. Cytoplasm > Perinuclear region.

Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.
UniProt: O75604
Gene ID: 9099
Synonyms: 41 kDa ubiquitin specific protease Antibody
41 kDa ubiquitin-specific protease Antibody
Deubiquitinating enzyme 2 Antibody
Ubiquitin carboxyl terminal hydrolase 2 Antibody
Ubiquitin carboxyl-terminal hydrolase 2 Antibody
ubiquitin specific peptidase 2 Antibody
Ubiquitin specific processing protease 2 Antibody
Ubiquitin specific protease 12 Antibody
Ubiquitin specific protease 9 Antibody
Ubiquitin specific protease, 41kD Antibody
Ubiquitin thioesterase 2 Antibody
Ubiquitin thiolesterase 2 Antibody
Ubiquitin-specific-processing protease 2 Antibody
Ubiquitin-specific-processing protease testis Antibody
UBP-t Antibody
UBP2_HUMAN Antibody
UBP41 Antibody
USP9 Antibody

Product Code - A10399
Size Price Quantity
50µl £148
100µl £243
200µl £372

or
Request a quotation
Contact us directly to order
  • call icon +44 (0)1223 298875
  • +44 (0)1223 281447
  • email icon orders@ab-y-ss.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe