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Anti-DIAPH3 Antibody

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ABclonal
A10351
Overview
Name: Anti-DIAPH3 Antibody
Description: Rabbit polyclonal antibody to DIAPH3.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human DIAPH3
Protein Length: 1193 (849)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).
Involvement in Disease: Auditory neuropathy, autosomal dominant, 1: A form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem.
Sequence Similarities: Belongs to the formin homology family. Diaphanous subfamily.
Post-Translational Modification: Ubiquitinated.
Cellular Location: Cytoplasm > Cytosol.

During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis.
UniProt: Q9NSV4
Gene ID: 81624
Synonyms: AN Antibody
AUNA1 Antibody
Dia2 Antibody
diap3 Antibody
DIAP3_HUMAN Antibody
DIAPH3 (phospho T1061 + T1061) Antibody
Diaphanous homolog 3 Antibody
Diaphanous homolog 3 (Drosophila) Antibody
Diaphanous related formin 3 Antibody
Diaphanous, Drosophila, homolog of, 3 Antibody
Diaphanous-related formin-3 Antibody
DKFZp434C0931 Antibody
DKFZp686A13178 Antibody
DRF3 Antibody
FLJ34705 Antibody
mDia2 Antibody
NSDAN Antibody
OTTHUMP00000018480 Antibody
Protein diaphanous homolog 3 Antibody
RP11-26P21.1 Antibody

Images
Western Blot - Anti-DIAPH3 Antibody from ABclonal (A10351) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using DIAPH3 antibody.

Product Code - A10351
Size Price Quantity
50µl £148
100µl £243
200µl £372

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