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Anti-DIAPH3 Antibody

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Description: Rabbit polyclonal antibody to DIAPH3.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q9NSV4
Gene ID: 81624
Immunogen: Recombinant protein of human DIAPH3
Protein Length: 1193 (849)
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: AN; DIA2; DRF3; AUNA1; NSDAN; diap3; mDia2
Purification: Affinity purification
Background: This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).
Involvement in Disease: Auditory neuropathy, autosomal dominant, 1: A form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem.
Sequence Similarities: Belongs to the formin homology family. Diaphanous subfamily.
Post-Translational Modification: Ubiquitinated.
Cellular Location: Cytoplasm > Cytosol.

During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis.

Western Blot - Anti-DIAPH3 Antibody from ABclonal (A10351) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using DIAPH3 antibody.

Product Code - A10351
Size Price Quantity
50µl £148
100µl £243
200µl £372

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