|Description:||Rabbit polyclonal antibody to DIAPH3.|
|Dilutions:||WB 1:500 - 1:2000|
|Immunogen:||Recombinant protein of human DIAPH3|
|Protein Length:||1193 (849)|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).|
|Involvement in Disease:||Auditory neuropathy, autosomal dominant, 1: A form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem.|
|Sequence Similarities:||Belongs to the formin homology family. Diaphanous subfamily.|
|Cellular Location:||Cytoplasm > Cytosol.
During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis.
DIAPH3 (phospho T1061 + T1061) Antibody
Diaphanous homolog 3 Antibody
Diaphanous homolog 3 (Drosophila) Antibody
Diaphanous related formin 3 Antibody
Diaphanous, Drosophila, homolog of, 3 Antibody
Diaphanous-related formin-3 Antibody
Protein diaphanous homolog 3 Antibody
Western blot analysis of extracts of various cell lines, using DIAPH3 antibody.