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Anti-STIL Antibody

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ABclonal
A10350
Overview
Name: Anti-STIL Antibody
Description: Rabbit polyclonal antibody to STIL.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human STIL
Protein Length: 1287
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124).
Tissue Specificity: Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer.
Involvement in Disease: Microcephaly 7, primary, autosomal recessive: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Post-Translational Modification: Ubiquitinated.
Cellular Location: Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole.
UniProt: Q15468
Gene ID: 6491
Synonyms: DKFZp686O09161 Antibody
MCPH7 Antibody
OTTHUMP00000009566 Antibody
SCL interrupting locus protein Antibody
SCL-interrupting locus protein Antibody
SCL/TAL1 interrupting locus Antibody
SIL Antibody
STIL_HUMAN Antibody
TAL 1 interrupting locus protein Antibody
TAL-1-interrupting locus protein Antibody

Images
Western Blot - Anti-STIL Antibody from ABclonal (A10350) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using STIL antibody.

Product Code - A10350
Size Price Quantity
50µl £148
100µl £243
200µl £372

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