phone icon
+44 (0)1223 298875

Anti-SLAMF6 Antibody

file icon Datasheet
ABclonal
A10338
Overview
Name: Anti-SLAMF6 Antibody
Description: Rabbit polyclonal antibody to SLAMF6.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human SLAMF6
Protein Length: 332
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).
Tissue Specificity: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes (PubMed:11489943). Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients (PubMed:22184727).
Post-Translational Modification: Phosphorylation in NK cells upon engagment by SLAMF6-expressing target cells is leading to receptor activation.
Cellular Location: Cell membrane.
UniProt: Q96DU3
Gene ID: 114836
Synonyms: Activating NK receptor Antibody
CD352 Antibody
KALI Antibody
KALIb Antibody
LY108 Antibody
MGC104953 Antibody
Natural killer T and B cell antigen Antibody
NK T B antigen Antibody
NK-, T-, and B-cell antigen Antibody
NK-T-B-antigen Antibody
NTB A Antibody
NTB-A Antibody
NTBA Antibody
NTBA receptor Antibody
SF2000 Antibody
SLAF6_HUMAN Antibody
SLAM family member 6 Antibody
SLAM family member 6 precursor Antibody
SLAM Family Receptor Antibody

Product Code - A10338
Size Price Quantity
50µl £148
100µl £243
200µl £372

or
Request a quotation
Contact us directly to order
  • call icon +44 (0)1223 298875
  • +44 (0)1223 281447
  • email icon orders@ab-y-ss.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe