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Anti-RNF138 Antibody

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ABclonal
A10304
Overview
Name: Anti-RNF138 Antibody
Description: Rabbit polyclonal antibody to RNF138.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human RNF138
Protein Length: 245aa
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Post-Translational Modification: Auto-ubiquitinated.
Cellular Location: Chromosome.

Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers.
UniProt: Q9CQE0
Gene ID: 51444
Synonyms: E3 ubiquitin protein ligase RNF138 Antibody
E3 ubiquitin-protein ligase RNF138 Antibody
hNARF Antibody
HSD 4 Antibody
HSD4 Antibody
MGC8758 Antibody
NARF Antibody
Nemo like kinase associated RING finger protein Antibody
Nemo-like kinase-associated RING finger protein Antibody
NLK associated RING finger protein Antibody
NLK-associated RING finger protein Antibody
RING finger protein 138 Antibody
ring finger protein 138, E3 ubiquitin protein ligase Antibody
RN138_HUMAN Antibody
STRIN Antibody

Product Code - A10304
Size Price Quantity
50µl £148
100µl £243
200µl £372

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