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Anti-EXOSC1 Antibody

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ABclonal
A10302
Overview
Name: Anti-EXOSC1 Antibody
Description: Rabbit polyclonal antibody to EXOSC1.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human EXOSC1
Protein Length: 195
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
Sequence Similarities: Belongs to the CSL4 family.
Cellular Location: Nucleus > Nucleolus. Nucleus. Cytoplasm.
UniProt: Q9Y3B2
Gene ID: 51013
Synonyms: 3'-5' exoribonuclease CSL4 homolog Antibody
CGI 108 Antibody
CGI-108 Antibody
CSL4 Antibody
CSL4 exosomal core protein homolog Antibody
CSL4, S. cerevisiae, homolog of Antibody
Csl4p Antibody
EXOS1_HUMAN Antibody
Exosomal core protein CSL4 Antibody
Exosome complex component csl4 Antibody
Exosome component 1 Antibody
hCsl4p Antibody
Homolog of yeast exosomal core protein CSL4 Antibody
p13 Antibody
RP11-452K12.9 Antibody
SKI4 Antibody
Ski4p Antibody

Images
Western Blot - Anti-EXOSC1 Antibody from ABclonal (A10302) - Antibody Supply Service
Western blot analysis of extract of various cells, using EXOSC1 antibody.

Product Code - A10302
Size Price Quantity
50µl £148
100µl £243
200µl £372

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