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Anti-DCPS Antibody

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ABclonal
A10299
Details
Description: Rabbit polyclonal antibody to DCPS.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q96C86
Gene ID: 28960
Immunogen: Recombinant protein of human DCPS
Protein Length: 337
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
Purification: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:1000 - 1:2000

Target (Information from UniProt)
Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
Tissue Specificity: Detected in liver, brain, kidney, testis and prostate.
Involvement in Disease: Al-Raqad syndrome: A syndrome characterized by delayed psychomotor development, moderate to severe intellectual disability, poor or absent speech, microcephaly, congenital hypotonia, and severe growth delay.
Sequence Similarities: Belongs to the HIT family.
Cellular Location: Cytoplasm. Nucleus.

Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.

Images
Western Blot - Anti-DCPS Antibody from ABclonal (A10299) - Antibody Supply Service
Western blot analysis of extract of HT-29 cells, using DCPS antibody.

Product Code - A10299
Size Price Quantity
50µl £148
100µl £243
200µl £372

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