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Anti-SDHB Antibody

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ABclonal
A1029
Overview
Name: Anti-SDHB Antibody
Description: Rabbit polyclonal antibody to SDHB.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human SDHB
Protein Length: 280
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Involvement in Disease: Pheochromocytoma: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.

Paragangliomas 4: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.

Paraganglioma and gastric stromal sarcoma: Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.

Cowden syndrome 2: A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. CWS2 inheritance is autosomal dominant.
Sequence Similarities: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
Cellular Location: Mitochondrion inner membrane.
UniProt: P21912
Gene ID: 6390
Synonyms: CWS2 Antibody
DHSB_HUMAN Antibody
FLJ92337 Antibody
Ip Antibody
Iron sulfur subunit Antibody
Iron sulfur subunit of complex II Antibody
Iron-sulfur subunit of complex II Antibody
mitochondrial Antibody
PGL 4 Antibody
PGL4 Antibody
SDH Antibody
SDH 1 Antibody
SDH1 Antibody
SDH2 Antibody
SDH2, homolog of Antibody
SDHIP Antibody
Succinate Dehydrogenase 1 Iron Sulfur Subunit Antibody
Succinate Dehydrogenase 2, S. cerevisiae, homolog of Antibody
Succinate dehydrogenase complex subunit B iron sulfur Antibody
Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein Antibody
succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Antibody
Succinate dehydrogenase iron sulfur protein Antibody
Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial Antibody
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit Antibody
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Antibody

Images
Western Blot - Anti-SDHB Antibody from ABclonal (A1029) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using SDHB antibody.

Product Code - A1029
Size Price Quantity
100µl £243
200µl £372

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