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Anti-RORC Antibody

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Name: Anti-RORC Antibody
Description: Rabbit polyclonal antibody to RORC.
Applications: WB
Dilutions: WB 1:1000 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human RORC
Protein Length: 518
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376).
Tissue Specificity: Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Involvement in Disease: Immunodeficiency 42: An autosomal recessive primary immunodeficiency characterized by increased susceptibility to concomitant candidiasis and mycobacteriosis. Candidiasis is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida. Mycobacteriosis is characterized by infections caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. IMD42 patients vaccinated with BCG are particularly at risk for developing disseminated mycobacterial infections.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Cellular Location: Nucleus.
UniProt: P51449
Gene ID: 6097
Synonyms: MGC129539 Antibody
NR1F1 Antibody
NR1F3 Antibody
Nuclear receptor ROR gamma Antibody
Nuclear receptor ROR-gamma Antibody
Nuclear receptor RZR gamma Antibody
Nuclear receptor RZR-gamma Antibody
Nuclear receptor subfamily 1 group F member 3 Antibody
RAR related orphan receptor C Antibody
RAR related orphan receptor C, isoform a Antibody
RAR related orphan receptor gamma Antibody
RAR-related orphan receptor alpha Antibody
RAR-related orphan receptor beta Antibody
RAR-related orphan receptor C Antibody
RAR-related orphan receptor gamma Antibody
Retinoic acid binding receptor gamma Antibody
Retinoid related orphan receptor gamma Antibody
Retinoid-related orphan receptor-gamma Antibody
ROR alpha + beta + gamma Antibody
ROR gamma Antibody
ROR1 Antibody
ROR2 Antibody
ROR3 Antibody
RORA Antibody
RORB Antibody
RORG Antibody
RZR GAMMA Antibody
RZRA Antibody
RZRG Antibody
TOR Antibody

Western Blot - Anti-RORC Antibody from ABclonal (A10240) - Antibody Supply Service
Western blot analysis of extract of various cells, using RORC antibody.

Product Code - A10240
Size Price Quantity
50µl £148
100µl £243
200µl £372

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