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Anti-KCNMB1 Antibody

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ABclonal
A10224
Overview
Name: Anti-KCNMB1 Antibody
Description: Rabbit polyclonal antibody to KCNMB1.
Applications: WB
Dilutions: WB 1:200 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human KCNMB1
Protein Length: 191
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Tissue Specificity: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
Sequence Similarities: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
Post-Translational Modification: N-glycosylated.
Cellular Location: Membrane.
UniProt: Q16558
Gene ID: 3779
Synonyms: BK channel beta subunit Antibody
BK channel subunit beta 1 Antibody
BKbeta Antibody
BKbeta1 Antibody
Calcium activated potassium channel subfamily M subunit beta 1 Antibody
Calcium activated potassium channel subunit beta Antibody
Calcium activated potassium channel subunit beta 1 Antibody
Charybdotoxin receptor subunit beta 1 Antibody
Hbeta1 Antibody
hslo beta Antibody
K(VCA)beta Antibody
K(VCA)beta 1 Antibody
KCNMB 1 Antibody
Large conductance Ca2+ activated K+ channel beta 1 subunit Antibody
Maxi K channel beta subunit Antibody
Maxi K channel subunit beta 1 Antibody
Maxi Potassium channel beta Antibody
Potassium large conductance calcium activated channel subfamily M beta member 1 Antibody
SLO beta Antibody
Slo beta 1 Antibody

Images
Western Blot - Anti-KCNMB1 Antibody from ABclonal (A10224) - Antibody Supply Service
Western blot analysis of extract of various cells, using KCNMB1 antibody.

Product Code - A10224
Size Price Quantity
50µl £148
100µl £243
200µl £372

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