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Anti-KCNMB1 Antibody

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ABclonal
A10224
Details
Description: Rabbit polyclonal antibody to KCNMB1.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q16558
Gene ID: 3779
Immunogen: Recombinant protein of human KCNMB1
Protein Length: 191
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1
Purification: Affinity purification
Background: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:200 - 1:2000

Target (Information from UniProt)
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Tissue Specificity: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
Sequence Similarities: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
Post-Translational Modification: N-glycosylated.
Cellular Location: Membrane.

Images
Western Blot - Anti-KCNMB1 Antibody from ABclonal (A10224) - Antibody Supply Service
Western blot analysis of extract of various cells, using KCNMB1 antibody.

Product Code - A10224
Size Price Quantity
50µl £148
100µl £243
200µl £372

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