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Anti-DSC2 Antibody

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ABclonal
A10211
Details
Description: Rabbit polyclonal antibody to DSC2.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q02487
Gene ID: 1824
Immunogen: Recombinant protein of human DSC2
Protein Length: 901
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: DG2; DSC3; CDHF2; ARVD11; DGII/III
Purification: Affinity purification
Background: This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:1000 - 1:2000

Target (Information from UniProt)
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Tissue Specificity: Expressed in epithelia, myocardium and lymph nodes.
Involvement in Disease: Arrhythmogenic right ventricular dysplasia, familial, 11: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Cellular Location: Cell membrane. Cell junction > Desmosome.

Images
Western Blot - Anti-DSC2 Antibody from ABclonal (A10211) - Antibody Supply Service
Western blot analysis of extract of various cells, using DSC2 antibody.

Product Code - A10211
Size Price Quantity
50µl £148
100µl £243
200µl £372

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