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Anti-DPP6 Antibody

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ABclonal
A10210
Details
Description: Rabbit polyclonal antibody to DPP6.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P42658
Gene ID: 1804
Immunogen: Recombinant protein of human DPP6
Protein Length: 865 (353)
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: VF2; DPL1; DPPX; MRD33
Purification: Affinity purification
Background: This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:1000 - 1:2000

Target (Information from UniProt)
Function: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).
Tissue Specificity: Expressed predominantly in brain.
Involvement in Disease: Familial paroxysmal ventricular fibrillation 2: A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity.

Mental retardation, autosomal dominant 33: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD33 patients manifest microcephaly and intellectual disability.
Sequence Similarities: Belongs to the peptidase S9B family.
Post-Translational Modification: N-glycosylated.
Cellular Location: Cell membrane.

Images
Western Blot - Anti-DPP6 Antibody from ABclonal (A10210) - Antibody Supply Service
Western blot analysis of extract of 293T cells, using DPP6 antibody.

Product Code - A10210
Size Price Quantity
50µl £148
100µl £243
200µl £372

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