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Anti-TNFSF9 Antibody

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ABclonal
A10202
Details
Description: Rabbit polyclonal antibody to TNFSF9.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P41273
Gene ID: 8744
Immunogen: Recombinant protein of human TNFSF9
Protein Length: 254
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: CD137L; 4-1BB-L
Purification: Affinity purification
Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Tissue Specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney.
Sequence Similarities: Belongs to the tumor necrosis factor family.
Cellular Location: Membrane.

Product Code - A10202
Size Price Quantity
50µl £148
100µl £243
200µl £372

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