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Anti-SERPINA1 Antibody

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ABclonal
A1015
Overview
Name: Anti-SERPINA1 Antibody
Description: Rabbit polyclonal antibody to SERPINA1.
Applications: WB
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human SERPINA1
Protein Length: 418
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Tissue Specificity: Ubiquitous. Expressed in leukocytes and plasma.
Involvement in Disease: Alpha-1-antitrypsin deficiency: A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.
Sequence Similarities: Belongs to the serpin family.
Post-Translational Modification: N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant.
Cellular Location: Secreted. Endoplasmic reticulum.

The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
UniProt: P01009
Gene ID: 5265
Synonyms: A1A Antibody
A1AT Antibody
A1AT_HUMAN Antibody
AAT Antibody
Alpha 1 antiproteinase Antibody
alpha 1 Antitrypsin Antibody
Alpha 1 antitrypsin null Antibody
Alpha 1 protease inhibitor Antibody
Alpha-1 protease inhibitor Antibody
Alpha-1-antiproteinase Antibody
alpha1 proteinase inhibitor Antibody
Alpha1AT Antibody
Dom1 Antibody
PI Antibody
PI1 Antibody
PRO2275 Antibody
Serine (or cysteine) proteinase inhibitor clade A member 1 Antibody
Serine protease inhibitor 1-1 Antibody
Serine protease inhibitor A1a Antibody
Serpin A1 Antibody
Serpin A1a Antibody
Serpin peptidase inhibitor clade A member 1 Antibody
Short peptide from AAT Antibody
SPAAT Antibody
Spi1-1 Antibody

Images
Western Blot - Anti-SERPINA1 Antibody from ABclonal (A1015) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using SERPINA1 antibody.
Immunohistochemistry - Anti-SERPINA1 Antibody from ABclonal (A1015) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human liver cancer tissue using SERPINA1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry - Anti-SERPINA1 Antibody from ABclonal (A1015) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human esophagus tissue using SERPINA1 antibody at dilution of 1:100 (x40 lens).

Product Code - A1015
Size Price Quantity
50µl £148
100µl £243
200µl £372

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