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Anti-TRPM4 Antibody

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ABclonal
A10146
Overview
Name: Anti-TRPM4 Antibody
Description: Rabbit polyclonal antibody to TRPM4.
Applications: WB
Dilutions: WB 1:200 - 1:1000
Reactivity: Human
Immunogen: Recombinant protein of human TRPM4
Protein Length: 1214
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Tissue Specificity: Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells.
Involvement in Disease: Progressive familial heart block 1B: A cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
Sequence Similarities: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily.
Post-Translational Modification: Phosphorylation by PKC leads to increase the sensitivity to Ca(2+).
Cellular Location: Cell membrane. Endoplasmic reticulum. Golgi apparatus.
UniProt: Q8TD43
Gene ID: 54795
Synonyms: 1110030C19Rik Antibody
AW047689 Antibody
Calcium-activated non-selective cation channel 1 Antibody
FLJ20041 Antibody
hTRPM4 Antibody
Long transient receptor potential channel 4 Antibody
LTrpC-4 Antibody
LTrpC4 Antibody
Melastatin 4 Antibody
Melastatin like 2 protein Antibody
Melastatin-4 Antibody
Melastatin-like 2 Antibody
Mls2s Antibody
PFHB1B Antibody
Transient receptor potential cation channel subfamily M member 4 Antibody
Transient receptor potential cation channel, subfamily M, member 4 Antibody
TRPM4B Antibody
TRPM4_HUMAN Antibody

Images
Western Blot - Anti-TRPM4 Antibody from ABclonal (A10146) - Antibody Supply Service
Western blot analysis of extracts of various cells, using TRPM4 antibody.

Product Code - A10146
Size Price Quantity
50µl £148
100µl £243
200µl £372

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