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Anti-SEMA4D Antibody

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ABclonal
A10136
Details
Description: Rabbit polyclonal antibody to SEMA4D.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q92854
Gene ID: 10507
Immunogen: Recombinant protein of human SEMA4D
Protein Length: 862
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:200 - 1:1000

Target (Information from UniProt)
Function: Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Tissue Specificity: Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Sequence Similarities: Belongs to the semaphorin family.
Cellular Location: Cell membrane.

Images
Western Blot - Anti-SEMA4D Antibody from ABclonal (A10136) - Antibody Supply Service
Western blot analysis of extracts of 293T cells, using SEMA4D antibody.

Product Code - A10136
Size Price Quantity
50µl £148
100µl £243
200µl £372

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