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Anti-NPC1L1 Antibody

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ABclonal
A10049
Details
Description: Rabbit polyclonal antibody to NPC1L1.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q9UHC9
Gene ID: 29881
Immunogen: Recombinant protein of human NPC1L1
Protein Length: 1359 (1332)
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:1000 - 1:4000

Target (Information from UniProt)
Function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Tissue Specificity: Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
Sequence Similarities: Belongs to the patched family.
Post-Translational Modification: Highly glycosylated.
Cellular Location: Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane.

Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.

Images
Western Blot - Anti-NPC1L1 Antibody from ABclonal (A10049) - Antibody Supply Service
Western blot analysis of extracts of various cells, using NPC1L1 antibody.

Product Code - A10049
Size Price Quantity
50µl £148
100µl £243
200µl £372

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