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Anti-IKKG Antibody

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ABclonal
A1003
Overview
Name: Anti-IKKG Antibody
Description: Mouse monoclonal antibody to IKKG.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human IKBKG
Protein Length: 419
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Involvement in Disease: Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked: A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by absence of sweat glands, sparse scalp hair, rare conical teeth and immunological abnormalities resulting in severe infectious diseases.

Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis and lymphedema: A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by the association of anhidrotic ectodermal dysplasia with severe immunodeficiency, osteopetrosis and lymphedema.

Immunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia: Patients manifest immunodeficiency not associated with other abnormalities, and resulting in increased susceptibility to infections. Patients suffer from multiple episodes of infectious diseases.

Immunodeficiency 33: A X-linked recessive form of Mendelian susceptibility to mycobacterial disease, a rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals.

Recurrent isolated invasive pneumococcal disease 2: Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.

Incontinentia pigmenti: A genodermatosis usually prenatally lethal in males. In affected females, it causes abnormalities of the skin, hair, eyes, nails, teeth, skeleton, heart, and central nervous system. The prominent skin signs occur in four classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation and dermal scarring.
Post-Translational Modification: Phosphorylation at Ser-68 attenuates aminoterminal homodimerization.
Cellular Location: Cytoplasm. Nucleus.

Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
UniProt: Q9Y6K9
Gene ID: 8517
Synonyms: IkB kinase associated protein 1 Antibody
IkB kinase subunit gamma Antibody
Inhibitor of nuclear factor kappa B kinase subunit gamma Antibody
AMCBX1 Antibody
FIP 3 Antibody
FIP-3 Antibody
FIP3 Antibody
Fip3p Antibody
I kappa B kinase gamma Antibody
I-kappa-B kinase subunit gamma Antibody
IkB kinase gamma subunit Antibody
IkB kinase subunit gamma Antibody
IkB kinase-associated protein 1 Antibody
Ikbkg Antibody
IKK gamma Antibody
IKK gamma (phospho S31) Antibody
IKK gamma (phospho S85) Antibody
IKK-gamma Antibody
IKKAP1 Antibody
IMD33 Antibody
Incontinentia pigmenti Antibody
Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma Antibody
Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma Antibody
Inhibitor of nuclear factor kappa-B kinase subunit gamma Antibody
IP Antibody
IP1 Antibody
IP2 Antibody
IPD2 Antibody
NEMO Antibody
NEMO_HUMAN Antibody
NF kappa B essential modifier Antibody
NF kappa B essential modulator Antibody
NF-kappa-B essential modifier Antibody
NF-kappa-B essential modulator Antibody
ZC2HC9 Antibody

Images
Western Blot - Anti-IKKG Antibody from ABclonal (A1003) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using IKBKG antibody.

Product Code - A1003
Size Price Quantity
100µl £243
200µl £372

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