|Description:||Rabbit polyclonal antibody to NOSIP.|
|Dilutions:||WB 1:500 - 1:2000|
|Immunogen:||Recombinant protein of human NOSIP|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).|
|Tissue Specificity:||Expressed in heart, brain and lung. Present in endothelial cells (at protein level).|
|Sequence Similarities:||Belongs to the NOSIP family.|
|Cellular Location:||Cytoplasm. Nucleus.
Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
|Synonyms:||CGI 25 Antibody
CGI25 protein Antibody
eNOS interacting protein Antibody
Nitric oxide synthase interacting protein Antibody
Western blot analysis of extracts of various cells, using NOSIP antibody.