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Anti-SCN8A Antibody

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ABclonal
A10007
Overview
Name: Anti-SCN8A Antibody
Description: Rabbit polyclonal antibody to SCN8A.
Applications: WB
Dilutions: WB 1:200 - 1:1000
Reactivity: Human
Immunogen: Recombinant protein of human SCN8A
Protein Length: 1980
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.
Tissue Specificity: Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.
Involvement in Disease: Cognitive impairment with or without cerebellar ataxia: A disorder characterized by markedly delayed cognitive and motor development, attention deficit disorder, and cerebellar ataxia. Features include bilateral esophoria, strabismatic amblyopia, unsustained gaze evoked nystagmus on horizontal gaze, ataxic gait, dysmetria in the upper limbs and dysarthria, with normal strength, tone, and reflexes.

Epileptic encephalopathy, early infantile, 13: A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. EIEE13 is a severe form consisting of early-onset seizures, features of autism, intellectual disability, ataxia, and sudden unexplained death in epilepsy.

Seizures, benign familial infantile, 5: A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS5 inheritance is autosomal dominant.
Sequence Similarities: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Post-Translational Modification: May be ubiquitinated by NEDD4L; which would promote its endocytosis.
Cellular Location: Cell membrane.
UniProt: Q9UQD0
Gene ID: 6334
Synonyms: CerIII Antibody
CIAT Antibody
EIEE13 Antibody
HBSC II Antibody
HH1 Antibody
hNa6/Scn8a voltage gated sodium channel Antibody
hNaN Antibody
hNE-Na Antibody
hPN3 Antibody
KIAA1356 Antibody
MED Antibody
Motor endplate disease Antibody
NAC1 Antibody
NAC2 Antibody
NAC3 Antibody
NaCh 6 Antibody
NaCh6 Antibody
Nav 1.6 Antibody
Nav1.6 Antibody
Nbna1 Antibody
NENA Antibody
Neuroendocrine sodium channel Antibody
pan Sodium Channel Antibody
peripheral nerve protein type 4 Antibody
Peripheral nerve sodium channel 3 Antibody
Peripheral nerve sodium channel 5 Antibody
Peripheral sodium channel 1 Antibody
PN 4 Antibody
PN1 Antibody
PN3 Antibody
PN4 Antibody
PN5 Antibody
SCN1 Antibody
SCN10A Antibody
SCN11A Antibody
SCN12A Antibody
SCN1A Antibody
SCN2A Antibody
SCN2A1 Antibody
SCN2A2 Antibody
SCN3A Antibody
SCN4A Antibody
SCN5A Antibody
SCN8A_HUMAN Antibody
SCN9A Antibody
Sensory neuron sodium channel 2 Antibody
SkM1 Antibody
SNS2 Antibody
Sodium channel protein brain I subunit alpha Antibody
Sodium channel protein brain II subunit alpha Antibody
Sodium channel protein brain III subunit alpha Antibody
Sodium channel protein cardiac muscle subunit alpha Antibody
Sodium channel protein skeletal muscle subunit alpha Antibody
Sodium channel protein type 1 subunit alpha Antibody
Sodium channel protein type 10 subunit alpha Antibody
Sodium channel protein type 11 subunit alpha Antibody
Sodium channel protein type 2 subunit alpha Antibody
Sodium channel protein type 3 subunit alpha Antibody
Sodium channel protein type 4 subunit alpha Antibody
Sodium channel protein type 5 subunit alpha Antibody
Sodium channel protein type 8 alpha subunit Antibody
Sodium channel protein type 8 subunit alpha Antibody
Sodium channel protein type 9 subunit alpha Antibody
Sodium channel protein type II subunit alpha Antibody
Sodium channel protein type III subunit alpha Antibody
Sodium channel protein type IV subunit alpha Antibody
Sodium channel protein type IX subunit alpha Antibody
Sodium channel protein type V subunit alpha Antibody
Sodium channel protein type VIII alpha subunit Antibody
Sodium channel protein type VIII subunit alpha Antibody
Sodium channel protein type X subunit alpha Antibody
Sodium channel protein type XI subunit alpha Antibody
Sodium channel voltage gated type VIII alpha Antibody
Sodium channel voltage gated type VIII alpha polypeptide Antibody
Sodium channel voltage gated type VIII alpha subunit Antibody
Voltage gated sodium channel subunit alpha Nav1.6 Antibody
Voltage-gated sodium channel subtype III Antibody
Voltage-gated sodium channel subunit alpha Nav1.1 Antibody
Voltage-gated sodium channel subunit alpha Nav1.2 Antibody
Voltage-gated sodium channel subunit alpha Nav1.3 Antibody
Voltage-gated sodium channel subunit alpha Nav1.4 Antibody
Voltage-gated sodium channel subunit alpha Nav1.5 Antibody
Voltage-gated sodium channel subunit alpha Nav1.6 Antibody
Voltage-gated sodium channel subunit alpha Nav1.7 Antibody
Voltage-gated sodium channel subunit alpha Nav1.8 Antibody
Voltage-gated sodium channel subunit alpha Nav1.9 Antibody

Images
Western Blot - Anti-SCN8A Antibody from ABclonal (A10007) - Antibody Supply Service
Western blot analysis of extracts of various cells, using SCN8A antibody.

Product Code - A10007
Size Price Quantity
50µl £148
100µl £243
200µl £372

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