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Anti-PDPN Antibody

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Name: Anti-PDPN Antibody
Description: Rabbit polyclonal antibody to PDPN.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human PDPN
Protein Length: 162
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
Tissue Specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
Sequence Similarities: Belongs to the podoplanin family.
Post-Translational Modification: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
Cellular Location: Membrane. Cell projection > Filopodium membrane. Cell projection > Lamellipodium membrane. Cell projection > Microvillus membrane. Cell projection > Ruffle membrane.

Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
UniProt: Q86YL7
Gene ID: 10630
Synonyms: Aggrus Antibody
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gp 36 Antibody
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gp36 Antibody
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HT1A 1 Antibody
HT1A1 Antibody
hT1alpha 1 Antibody
hT1alpha 2 Antibody
hT1alpha1 Antibody
hT1alpha2 Antibody
Lung type I cell membrane associated glycoprotein Antibody
Lung type I cell membrane associated glycoprotein isoform a Antibody
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OTS 8 Antibody
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OTTHUMP00000009640 Antibody
OTTHUMP00000044504 Antibody
PA2.26 Antibody
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Podoplanin Antibody
Podoplanin / gp36 Antibody
PSEC0003 Antibody
PSEC0025 Antibody
T1 alpha Antibody
T1 ALPHA GENE Antibody
T1-alpha Antibody
T1A Antibody
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TI1A Antibody
TIA 2 Antibody
TIA2 Antibody

Western Blot - Anti-PDPN Antibody from ABclonal (A0956) - Antibody Supply Service
Western blot analysis of extracts of 293T cell line, using PDPN antibody.

Product Code - A0956
Size Price Quantity
50µl £243
100µl £372
200µl £565

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