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Anti-CTHRC1 Antibody

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ABclonal
A0940
Details
Description: Rabbit polyclonal antibody to CTHRC1.
Category: Primary Antibodies
Applications: WB, IHC, FC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q96CG8
Gene ID: 115908
Immunogen: A synthetic peptide of human CTHRC1
Protein Length: 243
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: CTHRC1; Collagen triple helix repeat-containing protein 1; Protein NMTC1
Purification: Affinity purification
Background: This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100, FC 1:20 - 1:50

Target (Information from UniProt)
Function: May act as a negative regulator of collagen matrix deposition.
Tissue Specificity: Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.
Involvement in Disease: Barrett esophagus: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
Post-Translational Modification: N-glycosylated.
Cellular Location: Secreted > Extracellular space > Extracellular matrix.

Images
Western Blot - Anti-CTHRC1 Antibody from ABclonal (A0940) - Antibody Supply Service
Western blot analysis of extracts of A375 cell line, using CTHRC1 antibody.

Product Code - A0940
Size Price Quantity
100µl £243
200µl £372

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