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Anti-Stat2 Antibody

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ABclonal
A0913
Overview
Name: Anti-Stat2 Antibody
Description: Rabbit polyclonal antibody to Stat2.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: A synthetic peptide of human STAT2
Protein Length: 851
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).
Involvement in Disease: Immunodeficiency 44: An autosomal recessive disorder characterized by increased susceptibility to viral infection, resulting in some patients in encephalopathy and infection-associated neurologic decompensation.
Sequence Similarities: Belongs to the transcription factor STAT family.
Post-Translational Modification: Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.
Cellular Location: Cytoplasm. Nucleus.

Translocated into the nucleus upon activation by IFN-alpha/beta.
UniProt: P52630
Gene ID: 6773
Synonyms: Homo sapiens interferon alpha induced transcriptional activator Antibody
interferon alpha induced transcriptional activator Antibody
ISGF 3 Antibody
ISGF3 Antibody
MGC59816 Antibody
P113 Antibody
Signal transducer and activator of transcription 2 Antibody
signal transducer and activator of transcription 2 113kD Antibody
STAT113 Antibody
STAT2 (phospho Y631) Antibody
STAT2 (phospho Y690) Antibody
STAT2_HUMAN Antibody

Images
Western Blot - Anti-Stat2 Antibody from ABclonal (A0913) - Antibody Supply Service
Western blot analysis of extracts of HeLa cells lines, using STAT2 antibody.

Product Code - A0913
Size Price Quantity
100µl £243
200µl £372

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