|Description:||Rabbit polyclonal antibody to Stat2.|
|Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:200|
|Immunogen:||A synthetic peptide of human STAT2|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at 4℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).|
|Involvement in Disease:||Immunodeficiency 44: An autosomal recessive disorder characterized by increased susceptibility to viral infection, resulting in some patients in encephalopathy and infection-associated neurologic decompensation.|
|Sequence Similarities:||Belongs to the transcription factor STAT family.|
|Post-Translational Modification:||Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.|
|Cellular Location:||Cytoplasm. Nucleus.
Translocated into the nucleus upon activation by IFN-alpha/beta.
|Synonyms:||Homo sapiens interferon alpha induced transcriptional activator Antibody
interferon alpha induced transcriptional activator Antibody
ISGF 3 Antibody
Signal transducer and activator of transcription 2 Antibody
signal transducer and activator of transcription 2 113kD Antibody
STAT2 (phospho Y631) Antibody
STAT2 (phospho Y690) Antibody
Western blot analysis of extracts of HeLa cells lines, using STAT2 antibody.