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Anti-CD326 Antibody

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ABclonal
A0895
Overview
Name: Anti-CD326 Antibody
Description: Mouse monoclonal antibody to CD326.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human EpCAM
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Tissue Specificity: Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Involvement in Disease: Diarrhea 5, with tufting enteropathy, congenital: An intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum.

Hereditary non-polyposis colorectal cancer 8: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
Sequence Similarities: Belongs to the EPCAM family.
Post-Translational Modification: Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
Cellular Location: Lateral cell membrane. Cell junction > Tight junction.

Colocalizes with CLDN7 at the lateral cell membrane and tight junction.
UniProt: P16422
Gene ID: 4072
Synonyms: 17 1A Antibody
323/A3 Antibody
Adenocarcinoma associated antigen Antibody
Adenocarcinoma-associated antigen Antibody
Antigen identified by monoclonal Antibody
AUA1 Antibody
CD326 antigen Antibody
Cell surface glycoprotein Trop 1 Antibody
Cell surface glycoprotein Trop 2 Antibody
Cell surface glycoprotein Trop-1 Antibody
CO 17A Antibody
CO17 1A Antibody
CO17A Antibody
DIAR5 Antibody
EGP Antibody
EGP 2 Antibody
EGP2 Antibody
EGP314 Antibody
EGP40 Antibody
Ep CAM Antibody
Ep-CAM Antibody
EpCAM Antibody
EpCAM1 Antibody
EPCAM_HUMAN Antibody
Epithelial cell adhesion molecule Antibody
Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD) Antibody
Epithelial cell surface antigen Antibody
Epithelial cellular adhesion molecule Antibody
Epithelial glycoprotein Antibody
Epithelial glycoprotein 1 Antibody
Epithelial glycoprotein 314 Antibody
ESA Antibody
GA733 1 Antibody
GA733 2 Antibody
GA733-2 Antibody
gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein Antibody
gp4 Antibody
hEGP 2 Antibody
hEGP314 Antibody
HNPCC8 Antibody
Human epithelial glycoprotein 2 Antibody
KS 1/4 antigen Antibody
KS1/4 Antibody
KSA Antibody
Ly74 Antibody
Lymphocyte antigen 74 Antibody
M1S 1 Antibody
M1S2 Antibody
M4S1 Antibody
Major gastrointestinal tumor associated protein GA733 2 Antibody
Major gastrointestinal tumor-associated protein GA733-2 Antibody
mEGP314 Antibody
Membrane component chromosome 4 surface marker (35kD glycoprotein) Antibody
Membrane component, chromosome 4, surface marker Antibody
Membrane component, chromosome 4, surface marker 1 Antibody
MIC18 Antibody
MK 1 Antibody
Protein 289A Antibody
TACD1 Antibody
TACSTD1 Antibody
TROP1 Antibody
Tumor associated calcium signal transducer 1 Antibody
Tumor associated calcium signal transducer 2 precursor Antibody
Tumor-associated calcium signal transducer 1 Antibody

Images
Western Blot - Anti-CD326 Antibody from ABclonal (A0895) - Antibody Supply Service
Western blot analysis of extracts of HT-29 cells, using EpCAM antibody.

Product Code - A0895
Size Price Quantity
50µl £199
100µl £307
200µl £452

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