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Anti-ITGB4 Antibody

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ABclonal
A0857
Overview
Name: Anti-ITGB4 Antibody
Description: Rabbit polyclonal antibody to ITGB4.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human ITGB4
Protein Length: 1822
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
Tissue Specificity: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Involvement in Disease: Epidermolysis bullosa letalis, with pyloric atresia: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.

Generalized atrophic benign epidermolysis bullosa: A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
Sequence Similarities: Belongs to the integrin beta chain family.
Post-Translational Modification: Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins.
Cellular Location: Cell membrane. Cell membrane. Cell junction > Hemidesmosome.

Colocalizes with DST at the leading edge of migrating keratinocytes.
UniProt: P16144
Gene ID: 3691
Synonyms: CD 104 Antibody
CD104 Antibody
CD104 antigen Antibody
gp150 Antibody
Integrin beta 4 Antibody
Integrin beta 4 (phospho Y1494) Antibody
Integrin beta 4 (phospho Y1510) Antibody
Integrin beta 4 (phospho Y1526) Antibody
Integrin beta 4 subunit Antibody
Integrin beta-4 Antibody
ITB4_HUMAN Antibody
ITG B4 Antibody
ITGB 4 Antibody

Images
Western Blot - Anti-ITGB4 Antibody from ABclonal (A0857) - Antibody Supply Service
Western blot analysis of extracts of MCF7 cells lines, using ITGB4 antibody.

Product Code - A0857
Size Price Quantity
50µl £148
100µl £243
200µl £372

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