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Anti-YY1 Antibody

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ABclonal
A0856
Overview
Name: Anti-YY1 Antibody
Description: Rabbit polyclonal antibody to YY1.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:1000, IHC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human YY1
Protein Length: 414
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).
Sequence Similarities: Belongs to the YY transcription factor family.
Post-Translational Modification: Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.
Cellular Location: Nucleus matrix.

Associated with the nuclear matrix.
UniProt: P25490
Gene ID: 7528
Synonyms: CF1 Antibody
Delta Antibody
Delta transcription factor Antibody
INO80 complex subunit S Antibody
INO80S Antibody
NF E1 Antibody
NF-E1 Antibody
NFE1 Antibody
OTTHUMP00000197459 Antibody
Transcriptional repressor protein YY1 Antibody
TYY1_HUMAN Antibody
UCR motif DNA binding protein Antibody
UCRBP Antibody
Yin and yang 1 Antibody
Yin and Yang 1 protein Antibody
Yin Yang 1 Antibody
Ying Yang 1 Antibody
YY 1 Antibody
YY 1 transcription factor Antibody
YY-1 Antibody
YY1 transcription factor Antibody

Images
Western Blot - Anti-YY1 Antibody from ABclonal (A0856) - Antibody Supply Service
Western blot analysis of extracts of Y79 cell line, using YY1 antibody.

Product Code - A0856
Size Price Quantity
100µl £243
200µl £372

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